Risk of Obstructive Sleep Apnea in Adults with Resistant Hypertension

The risk of obstructive sleep apnea (OSA) in patients with resistant hypertension (RH) has not been well-quantified. We sought to evaluate the OSA RH compared those treated but non-resistant (non-RH) using a time-dependent-exposure analysis. conducted retrospective cohort study (hypertension diagnosis + ≥2 antihypertensive drug claims within 1 year) IBM MarketScan® commercial database from January 2008 December 2019. excluded without 12 months continuous enrollment before second fill date (index entry) and having outcome 12-month pre-index period. employed Cox proportional hazard regression as dependent variable, time-dependent exposure (non-RH vs. RH) baseline covariates independent variables. Of 1,375,055 hypertension, 13,584 were categorized exposed RH. In multivariable hazards model, was associated 60% increased (adjusted ratio (aHR): 1.60; 95% CI, 1.52–1.68) non-RH exposure. Findings suggest that RH, non-RH, is higher incident OSA.